The authors develop an analysis of education. They show how education carries an essentially arbitrary cultural scheme which is actually based on power. More widely, the reproduction of culture through education is shown to play a key part in the reproduction of the whole social system.

Édition commentée des deux fragments de manuscrits littéraires grecs découverts dans la trésorerie du palais d'Aï-Khanoum, dans un contexte daté de 145 av. J.-C. Ces manuscrits avaient été rédigés dans des officines méditerranéennes et sont paléographiquement datables entre le milieu du IIIe et le début du IIe s. av. J.-C. Le premier texte, rédigé sur papyrus, est un dialogue philosophique platonicien ou aristotélicien relatif à la théorie platonicienne des Idées ; le second, rédigé sur parchemin en trimètres iambiques, relève peut-être (...) du genre théâtral. Leur présence à Aï Khanoum atteste l'existence d'une bibliothèque dans le palais de cette cité. (shrink)

Rousseau a bouleversé la compréhension du phénomène humain. Treize études prennent la mesure de cette révolution théorique qui touche l'image de soi, l'idée du bien, les attentes politiques, la perception de la société. Chacune scrute la radicalité de la science de l'homme qu'il a inaugurée.

Un petit bloc de calcaire a été apporté au musée de Thèbes en juillet 1990, sans que son origine ait été annoncée, relevée ou consignée. Il s'agit d'une base de statue portant une inscription qui se terminait par la signature de Lysippe de Sicyone. La signature était précédée d'une épigramme de quatre vers. Le poème fait allusion à la « patrie » du personnage honoré, en précisant que c'est cette patrie même qui a choisi pour chef à la guerre l'homme (...) dont la statue se dressait sur la base. Le poème ajoute qu'il a « fait grandir la gloire de Thèbes, l'intrépide ». On peut donc admettre que la « patrie » de l'officier n'est autre que Thèbes et par conséquent que l'origine de l'inscription est thébaine. Enfin, l'inscription donne les noms du dédicant, Hippias fils d'Érotion, et du dieu auquel la statue était dédiée, Zeus Saôtas. La base et son inscription sont publiées ici pour la première fois dans leur intégralité. (shrink)

Ce recueil vise à interroger un versant moins connu, mais essentiel, de la pensée de Gadamer, sa méditation des philosophes grecs, des Présocratiques à Plotin, qui occupe un tiers de ses œuvres complètes.

L'omniprésence des images dans la société mass-médiatique est corrélative de leur évanescence et du constant renouvellement qui conditionne le processus de leur consommation. Leur omnipotence se réduit ainsi à celle de stimuli destinés à induire des comportements. Or, il convient d'autant plus de revenir d'une telle exténuation de l'image que cette dernière constitue l'une des dimensions essentielles du déploiement de la vie humaine. L'image est traditionnellement rapportée à l'activité imaginante d'un sujet. Mais, s'il est vrai que l'étoffe des hommes et (...) des choses qui se donnent à voir dans le paraître sensible d'une image n'existe pas coupée d'un tel paraître, l'esthétique relève aussi de l'ontologie et sa tâche est de nous ré-apprendre à contempler les images. Au regard de la clarté et de la distinction conférées par la théorie à notre appréhension des choses, la détermination positive des images ne tient-elle pas en effet au fait que c'est dans leur dimension qu'il nous est donné de faire l'expérience vive du paraître de ces choses, jusqu'à l'extrême de l'horreur, du merveilleux et du sacré? (shrink)

De la scolastique médiévale au XIXe siècle, la tradition philosophique a cherché à saisir l'unité des directions en lesquelles elle se déploie à travers des métaphores, celle de l'arbre par exemple, ou en élaborant des systèmes dont le XXe siècle semble bien avoir fait le deuil. Comment donc penser l'hétérogénéité de ces directions, qui font l'ampleur d'une pensée, si ce n'est en les reconduisant à des modalités de l'existence qui en constituent le sol? Cet ouvrage s'est ainsi proposé de recueillir (...) le déploiement de la philosophie lorsqu'elle pense le mythique, l'esthétique et le logique, en partant de cette réflexion sur l'existence. Publié en l'honneur de Maryvonne Perrot, il se clôt par un triple hommage à sa personne, le premier d'entre eux témoignant du rayonnement international qu'elle a contribué à donner au Centre Gaston Bachelard, et ainsi à l'Université de Bourgogne. (shrink)

The present work is aimed at investigating the effects of myocardial infarction and ischemia on induction of ventricular fibrillation. Electrophysiologic effects of global and local ischemia (variation of the dispersion of refractory periods as well as conduction velocity) on initiation of reentry mechanisms was studied by means of computer simulations based on a cellular automata model of propagation of activation wave through a ventricular surface element. A local area of ischemia where effects of the dispersion of refractory periods are investigated (...) is then simulated. This is made using a Gaussian distribution characterized by its mean and standard deviation. These simulations show that ischemia is capable of initiating reentry phenomena which propagate through the whole ventricle; they are responsible for ventricular fibrillation which causes sudden cardiac death, even when ischemia only involves limited parts of the myocardium. Statistical study of the probability of reentries as a function of both of the size of ischemic zones and the rate of dispersion of refractory periods shows that the latter parameter is of primary importance in triggering cardiac reentries. (shrink)

This article deals with the integration of ethical reflection into the research practices of the project at the Lille Nord-Pas-de-Calais genopole: “Multifactorial genetic pathologies and therapeutic innovations”. The general hypothesis of this text is that changes in research practices in biology (mainly through the use of bioinformatics) imply changes in medical practices, which require critical reflection. This hypothesis could be broken down into three sub-hypotheses: (1) Research in biology is undergoing a complete transformation; (2) Research in biology is a cultural (...) practice, which cannot be reduced to a simple cognitive action; (3) Research in biology is a techno-scientific practice. As for the method, the aim of our research at the Medical Ethics Centre is to elucidate the philosophical and ethical range of biomedical practices. This work entails a double task for reflection. On the one hand, from the revelation of ethical tensions present in these practices, we have to think about what is at stake in these practices, and more broadly in society. On the other hand, we have to analyse the conditions enabling the actors to assume the significance of ethical reflection in their practices. The method set up to undertake this double task could be qualified as “narrative hermeneutics”, as its aim is to attempt to interpret the stakes in practices from proximity with these practices and from what their actors have to say about them. The text then goes on to analyse more specifically the emergence and place of bioinformatics in present-day biomedical research. (shrink)

The dynamics of the "Etang de Berre", a brackish lagoon situated close to the French Mediterranean sea coast, is strongly disturbed by freshwater inputs coming from an hydroelectric power station. The system dynamics has been described as a sequence of daily typical states from a set of physicochemical variables such as temperature, salinity and dissolved oxygen rates collected over three years by an automatic sampling station. Each daily pattern summarizes the evolution, hour by hour of the physicochemical variables. This article (...) presents results of forecasts of the states of the system subjected to the simultaneous effects of meteorological conditions and freshwater releases. We recall the main step of the classification tree method used to build up the predictive model (Classification and Regression Trees, Breiman et al., 1984) and we propose a transfer procedure in order to test the stability of the model. Results obtained on the Etang de Berre data set allow us to describe and predict the effects of the environmental variables on the system dynamics with a margin of error. The transfer procedure applied after the tree building process gives a maximum gain in prediction accuracy of about 15%. (shrink)

This volume of the Amsterdam edition of the Latin texts of Erasmus deals with education and learning, and the mastery of Latin. It presents a critical edition of the Latin texts of De pueris instituendis, De ratione studii , De conscribendis epistolis and Ciceronianus.

Glycerol is a small and simple molecule produced in the breakdown of glucose, proteins, pyruvate, triacylglycerols and other glycerolipid, as well as release from dietary fats. An increasing number of observations show that glycerol is probably involved in a surprising variety of physiopathologic mechanisms. Glycerol has long been known to play fundamental roles in several vital physiological processes, in prokaryotes and eukaryotes, and is an important intermediate of energy metabolism. Despite some differences in the details of their operation, many of (...) these mechanisms have been preserved throughout evolution, demonstrating their fundamental importance. In particular, glycerol can control osmotic activity and crystal formation and then act as a cryoprotective agent. Furthermore, its properties make it useful in numerous industrial, therapeutic and diagnostic applications. Few studies have focussed directly on glycerol, however, and while its metabolism is increasingly well documented, much of the details remain unknown. Considering the importance of glycerol in multiple vital physiological processes, its study could help unlock important physiopathological mechanisms. BioEssays 23:534–542, 2001. © 2001 John Wiley & Sons, Inc. (shrink)

Le XXe siècle a été celui d'un éclatement sans précédent des formes traditionnelles de l'art, et donc aussi de son essence ou de son "idée". Est-ce à dire qu'un héritage entier de sens et de culture a été dilapidé en cet âge qu'on a dit être celui de la "fin de l'art"? Doit-on au contraire penser qu'héritage il y a bel et bien eu, sur un mode critique et selon des logiques qui ne firent peut-être pas sans raison? Loin d'être (...) dépourvus de sens, les signes contemporains de l'art - restes, bribes, traces, "symptômes" divers - sollicitent en fait plus que jamais les interprétations. C'est pourquoi nous avons estimé pouvoir, et même devoir, poser les questions suivantes : - Que fait donc l'art, de lui-même et de son histoire, à l'époque de son an-archie eidétique? - Que peuvent en dire aujourd'hui les théories esthétiques et philosophiques? - Sous quelle forme de fidélité critique à leur tradition respective le peuvent-elles? (shrink)

BackgroundIn the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort, participants underwent magnetic resonance imaging (MRI) of the brain, heart, and abdomen, that generated incidental findings (IFs). The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies.MethodsBetween 2013 and 2019, 8252 participants (...) (mean age 58 ± 9 years, 54% women) were recruited with a follow-up questionnaire administered to 909 participants (40% response rate) at 1-year. The CAHHM policy followed a restricted approach, whereby routine feedback on IFs was not provided. Only IFs of severe structural abnormalities were reported.ResultsSevere structural abnormalities occurred in 8.3% (95% confidence interval 7.7–8.9%) of participants, with the highest proportions found in the brain (4.2%) and abdomen (3.1%). The majority of participants (97%) informed of an IF reported no change in quality of life, with 3% of participants reporting that the knowledge of an IF negatively impacted their quality of life. Furthermore, 50% reported increased stress in learning about an IF, and in 95%, the discovery of an IF did not adversely impact his/her life insurance policy. Most participants (90%) would enrol in the study again and perceived the MRI scan to be beneficial, regardless of whether they were informed of IFs. While the implications of a restricted approach to IF management was perceived to be mostly positive, a degree of diagnostic misconception was present amongst participants, indicating the importance of a more thorough consent process to support participant autonomy.ConclusionThe management of IFs from research MRI scans remain a challenging issue, as participants may experience stress and a reduced quality of life when IFs are disclosed. The restricted approach to IF management in CAHHM demonstrated a fair fulfillment of the overarching ethical principles of respect for autonomy, concern for wellbeing, and justice. The approach outlined in the CAHHM policy may serve as a framework for future research studies.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/nct02220582. (shrink)

Comment Sortir de la Terreur. by Bronislaw Baczko The Kiss of Lamourette. by Robert Darnton Les Origines Culturelles de la Revolution Francaise. by Roger Chartier Naissance du Journal Revolutionnaire. by Claude Labrosse; Pierre Retat "Mere Words," The Journal of Modern History, June 1991. by Dorinda Outram Revolutionary News: The Press in France 1789-1799. by Jeremy D. Popkin.

PIERRE REY. — Connaître personnellement un auteur, c’est un peu superposer une voix à une parole... Après son décès, les médias ont commenté votre relation avec Claude Nougaro. Pourriez-vous nous en dire un mot ?DOMINIQUE BAUDIS. — Le lien entre Claude et moi, c’est évidemment Toulouse. Pour l’anecdote, je l’ai connu au moment..

New concepts may prove necessary to profit from the avalanche of sequence data on the genome, transcriptome, proteome and interactome and to relate this information to cell physiology. Here, we focus on the concept of large activity-based structures, or hyperstructures, in which a variety of types of molecules are brought together to perform a function. We review the evidence for the existence of hyperstructures responsible for the initiation of DNA replication, the sequestration of newly replicated origins of replication, cell division (...) and for metabolism. The processes responsible for hyperstructure formation include changes in enzyme affinities due to metabolite-induction, lipid-protein affinities, elevated local concentrations of proteins and their binding sites on DNA and RNA, and transertion. Experimental techniques exist that can be used to study hyperstructures and we review some of the ones less familiar to biologists. Finally, we speculate on how a variety of in silico approaches involving cellular automata and multi-agent systems could be combined to develop new concepts in the form of an Integrated cell (I-cell) which would undergo selection for growth and survival in a world of artificial microbiology. (shrink)

Writing involves risks—the risk that one will be misunderstood, the risk of being persecuted, the risks of being made a champion for causes in which one does not believe, this risk of inadvertently supporting a reader’s prejudices, to name a few. In trying to give expression to what is true, the writer must “clear a passage within the agitated world of passions,” an undertaking that always to some extent fails: writers are never the master of their own speech. In _Writing: (...) The Political Test, _France’s leading political philosopher, Claude Lefort, illuminates the process by which writers negotiate difficult path to free themselves from the ideological and contextual traps that would doom their attempts to articulate a new vision. Lefort examines writers whose works provide special insights into this problem of risk, both literary artists and political philosophers. Among them are Salman Rushdie, Sade, Tocqueville,m Machiavelli, Leo Strauss, Orwell, Kant, Robespierre, Guizot, and Pierre Clastres. In Tocqueville, for example, Lefort finds that the author’s improvisatory and open-ended expression represents the character of the democratic experience. Orwell’s work on totalitarianism shows up the totalitarian subject’s complicity in this political regime. And Rushdie is remarkable for his solid attack on relativism. With the character and fate of the political forms of modernity, democracy, and totalitarianism a central theme, Lefort concludes with some reflections on the collapse of the Soviet Union. This intriguing and accessible exploration of literature’s political aspects and political philosophy’s literary ones will be welcomed by those who have been stymied by current efforts to bridge these two fields. Taken together, the essays in this volume also stand as an intellectual autobiography of Lefort, making it an excellent introduction to his work for less experience students of political theory or philosophy. (shrink)